NIH Building 10, E-Wing Renovation

Bethesda, Maryland

The culmination of a two phase adaptive re-use project for the National Institutes of Health, this renovation converts the fourteen-story E-wing of Building 10 into new clinical program area, research laboratories, lab support, teaching facilities, offices, and building support space for approximately 800 personnel. This complex, phased transformation involved working within the fully operational 2.5 million square foot Warren Grant Magnuson Clinical Center, originally constructed in 1955. The new facility also includes a state-of-the-art cGMP laboratory to produce clinical supplies for autologous cell therapies, and continuing education space for the Foundation for Advanced Education in the Sciences (FAES).

Client: National Institutes of Health
Size: 250,000 square feet
Completion Date: 2024
Sustainability: LEED Certified

The renovation transforms former patient care, laboratory areas, and support space into specialty lab programs, like those that support the Clinical Center’s Transfusion Medicine Program’s (DTM) patient and donor aphaeresis and BSL-2 laboratories, as well as BSL-2 research laboratories for NIH Institutes.

Building 10 houses nine of the Institute's key research centers including clinical and biomedical laboratory spaces.

Laboratory levels 2-11 are color coded green, blue, and orange by floor for wayfinding purposes. The color translates to many of the key features, from custom resin panels highlighting the vertical plumbing chases at sink locations, to custom trays in the corridors housing data and AV cables. Colored felt panels help absorb hallway noise and add visual appeal to the long, white thoroughfares, while a custom colored handrail/crash rail provides additional support.

Warren Grant Magnuson Clinical Center boasts 2.5 million square feet and was made from seven million bricks. The Center has more than 5,000 rooms and totals nine miles of corridor.

The E-Wing encompasses 250,000 square feet across 14 floors.

The cGMP facility is designed to be flexible, and focuses on making Phase 1 and 2 clinical supplies of numerous types of cell therapies.

12-E cGMP Cell Processing Facility

Located on the 12th floor of Building 10, this cGMP facility supports the Clinical Center’s Department of Transfusion Medicine, Cell Processing section. Other than some shared utilities, the design is independent of the renovated E-Wing operation and house systems, as it has dedicated systems specific to NIH DRM Chapter 13 standards for aseptic facilities. It will be pivotal for human therapies and clinical trials performed at the National Institutes of Health.

Transparent windows and sliding doors at the air lock entries within this return corridor bring daylight into the ISO-7 suites.

The seven advanced suites have been designed to accommodate a variety of product types and hazards.

ISO-7 Medium Risk Tissue Culture Suite

Perkins&Will's clear understanding of laboratory design has been instrumental in finding creative ways to generate functionality in limited spaces. They have been highly receptive and flexible in working with NIH staff to translate our needs into workable solutions.

William W. Ward, Deputy Chief, Department of Transfusion Medicine, NIH Clinical Center

FAES provides continuing education opportunties and support services to NIH and the biomedical community.

Foundation for Advanced Education in the Sciences (FAES)

FAES is a non-profit organization offering advanced educational opportunities at the cutting edge of biomedical science, with programs that complement the work of NIH. Located on level B-2 above the mechanical floor, the space provides large, interactive, and highly-flexible teaching labs and assembly space, featuring the latest instructional research technologies.

Project Team

Joe Popp

Paul Harney

James Levin

NIH Building 10, E-Wing Renovation

Project Team

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